Phospholipase A2Activity in Gingival Crevicular Fluid from Patientswith Periodontal Disease: A possible Marker of Disease Activity

[摘要] The activity of phospholipase A2in human gingival crevicular fluid(GCF) associated with periodontal disease was demonstrated. Basedupon the presence or absence of bleeding on probing (BOP), which isa marker for the disease activity, there were higher levels of theenzyme activity in BOP positive, than in negative sites. When theBOP positive sites became negative after periodontal therapy, theenzyme activity decreased dramatically to almost undetectablelevels. There were no significant differences between the activitybefore and after treatment when the BOP positive sites remainedunchanged. These results suggest that the activity in GCF reflectsperiodontal disease conditions and that it can be used as a markerfor disease activity.

[学科分类] 生理学与病理学