Cromoglycate and Nedocromil: Influence on Airway Reactivity

[摘要] Although basic mechanisms of bronchial hyper-responsiveness (BHR)are still incompletely understood, inflammation of airways is likelyto play a fundamental role in modulating BHR in patients withasthma. The involvement of several inflammatory cells (eosinophils,mast cells, lymphocytes, neutrophils, macrophages and platelets) andof bioactive mediators secreted by these cells in the pathogenesisof asthma is well documented. Sodium cromoglycate and nedocromilsodium are two pharmacological agents which have anti-allergic andanti-inflammatory properties. Their clinical effectiveness in mildto moderate asthma, and the capacity to reduce BHR under differentnatural and experimental conditions, make them valuable drugs formaintenance therapy in patients with asthma.

[学科分类] 生理学与病理学