Interleukin-5 Potentiates Sulfidopeptide Leukotriene Production by Human Eosinophils

[摘要] Interleukin-5 (IL-5) has been shown to be a selective eosinophilgrowth and differentiation factor. In the present study, the effectof recombinant human IL-5 on human eosinophil sulfidopeptideleukotriene production was investigated. IL-5 did not affectleukotriene synthesis in unstimulated eosinophils. However, IL-5potentiated leukotriene synthesis by eosinophils stimulated withserum treated zymosan (STZ) or the calcium ionophore A23187 by69% and 135%, respectively. The priming effect of IL-5was dose dependent, with significant stimulation occurring at 1 000U/ml for STZ and 100-1 000 U/ml for A23187. Pre-incubation with IL-5did not increase leukotriene synthesis further.

[学科分类] 生理学与病理学