Corticosteroid-Sparing Effect of Chromoglycate Sodium and Nedocromil

[摘要] The most appropiate management for bronchial asthma is the controlof airway inflammation. Corticosteroids are the most effectiveanti-inflammatory drugs available, but they have a number of sideeffects; most of these are dose-dependent. In children, asthmacontrol should be accomplished with low steroid doses possibly givenby inhalation. In a double-bind placebo-controlled crossover study agroup of children with mild to moderate asthma received NED 16mg/day or BDP 400 μg/day. Values for FEV1, PEF, symptoms useofbronchodilators overlapped, whereas bronchial hyper-responsivenessassessed by histamine bronchoprovocation challenge was better withBDP than NED. In another case, one boy with high bronchialhyper-reactivity assessed by provocation test with hypertonicsolution, experienced a significant improvement only after 2 weeksof therapy with Deflazacort (2 mg/Kg/day) followed by 4 months oncombined treatment with NED (16 mg/day) and BDP (300 μ/day). Authorsconclude that NED could have a steroidsparing effect over long-term use.

[学科分类] 生理学与病理学