In vitroSuperoxide Production by Peripheral Neutrophils from Patients with Inflammatory Bowel Disease

[摘要] Activated polymorphonuclear leucocytes, which are accumulated ininflammatory lesions of inflammatory bowel disease, produce tissuedestructive, oxygen derived free radicals and other inflammatorymediators. The PMN superoxide production elicited byformyl-methionyl-leucyl-phenylalanine or the complement splitproduct 5a were compared in IBD and healthy volunteers.Significantly reduced superoxide production was found in PMNs frompatients with Crohn's disease as compared to normal controls,when fMLP or CSa were used as stimulants (p<0.001andp<0.01, respectively), whereas no differences were found whenulcerative colitis patients were compared to normal controls (p>0.05).The enhanced oxygen derived free radical productionpreviously reported in active IBD, and especially in CD intestinallesions, may either be due to an accumulation of productivephagocytes or to a change of the inflammatory profile of these cellswhen migrating into intestinal lesions, possibly due to interactionwith other mediators (e.g. adhesion molecules and interleukins).

[学科分类] 生理学与病理学