Neurogenic Inflammation of Guinea-Pig Bladder

[摘要] Capsaicin, substance P, and ovalbumin, instilled into the bladdersof naive and ovalbumin (OVA) sensitized guineapigs causedinflammation, as indicated by increased vascular permeability.Histological changes after exposure to these compounds progressedwith time from intense vasodilatation to marginalization ofgranulocytes followed by interstitial migration of leukocytes.Invitroincubation of guinea-pig bladder tissue with substance P andovalbumin stimulated release of prostaglandin D2and leukotrienes.Invitroincubation of bladder tissue with capsaicin, OVA,prostaglandin D2, leukotriene C4, histamine, or calcium ionophoreA-23587 all stimulated substance P release. These data suggest thatbladder inflammation initiated by a variety of stimuli could lead toa cyclic pattern of release of inflammatory mediators andneuropeptides, which could result in amplification and persistenceof cystitis after the inciting cause has subsided.

[学科分类] 生理学与病理学