Expression and Function of Hypoxia Inducible Factor-1αand Vascular Endothelial Growth Factor in Pulp Tissue of Teeth under Orthodontic Movement

[摘要] Orthodontic force may lead to cell damage, circulatory disturbances, and vascular changes of the dental pulp, which make a hypoxic environment in pulp. In order to maintain the homeostasis of dental pulp, hypoxia will inevitably induce the defensive reaction. However, this is a complex process and is regulated by numerous factors. In this study, we established an experimental animal model of orthodontic tooth movement to investigate the effects of mechanical force on the expression of VEGF and HIF-1αin dental pulp. Histological analysis of dental pulp and expressions of HIF-1αand VEGF proteins in dental pulp were examined. The results showed that inflammation and vascular changes happened in dental pulp tissue in different periods. Additionally, there were significant changes in the expression of HIF-1αand VEGF proteins under orthodontic force. After application of mechanical load, expression of HIF-1αand VEGF was markedly positive in 1, 3, 7 d, and 2 w groups, and then it weakened in 4 w group. These findings suggested that the expression of HIF-1αand VEGF was enhanced by mechanical force. HIF-1αand VEGF may play an important role in retaining the homeostasis of dental pulp during orthodontic tooth movement.

[学科分类] 生理学与病理学