TNF and PGE2in human monocyte-derived macrophages infected withChlamydia trachomatis

[摘要] In this study levels of prostaglandin E2(PGE2), tumour necrosis factor (TNF) and interleukin-1 (IL-1) alpha in medium from monocyte derived macrophages (MdM) infected withChlamydia trachomatis(L2/434/Bu or K biovars). TNF and PGE2were found in both cases while IL-1 alpha was not detected. Both TNF and PGE2levels were higher in the medium of the MdM infected with K biovars. TNF reached maximum levels 24 h postinfection, and then declined, while PGE2levels increased continuously during the infection time up to 96 h post-infection. Addition of dexamethasone inhibited production of TNF and PGE2. Inhibition of PGE2production by indomethacin resulted in increased production of TNF, while addition of PGE2caused partial inhibition of TNF production from infected MdM.

[学科分类] 生理学与病理学