Cerebellar and Hippocampal Activation During Eyeblink Conditioning Depends on the Experimental Paradigm: A MEG Study

[摘要] The cerebellum and the hippocampus arekey structures for the acquisition of conditionedeyeblink responses. Whereas the cerebellumseems to be crucial for all types of eyeblinkconditioning, the hippocampus appears to beinvolved only in complex types of learning. Weconducted a differential conditioning study toexplore the suitability of the design formagnetencephalography (MEG). In addition,we compared cerebellar and hippocampalactivation during differential delay and traceconditioning. Comparable conditioning effectswere seen in both conditions, but a greaterresistance to extinction for trace conditioning.Brain activation differed between paradigms:delay conditioning provoked activation only inthe cerebellum and trace conditioning only inthe hippocampus. The results reflect differentialbrain activation patterns during the two typesof eyeblink conditioning.

[学科分类] 精神健康和精神病学