TP53Mutations andHBXStatus Analysis in Hepatocellular Carcinomas from Iran: Evidence for Lack of Association between HBV Genotype D andTP53 R249SMutations

[摘要] High incidence of HCC is mostly due to the combination of two major risk factors, chronic infection with hepatitis B (HBV) and/or C (HCV) viruses and exposure to the mycotoxin aflatoxin B1, which induces a particular mutation at codon 249 inTP53 (R249S). Eight genotypes of HBV are diversely found in high and low incidence areas. Regardless of documented strong associations betweenTP53 R249Smutation and HBV genotypes B, C, Aor E, there is no report of such association for genotype D despite of the presence ofaflatoxin in areas with high prevalence of HBV genotype D. In Iran, 3% of the population is chronically infected with HBV, predominantly genotype D. Twenty-one histologically confirmed HCC cases from Iran were analyzed forTP53 R249Sand HBV double mutations 1762T/1764A, hallmarks of more pathogenic forms of HBV. We did not detect any of these mutations. In addition, we report the only case identified so far carrying bothR249Smutation and chronic HBV genotype D, a patient from The Gambia in West Africa. This paper suggests that association between HBV genotype D and aflatoxin-inducedTP53mutation is uncommon, explaining the relatively lower incidence of HCC in areas where genotype D is highly prevalent.

[学科分类] 传染病学