Mutations inTP53andCTNNB1in Relation to Hepatitis B and C Infections in Hepatocellular Carcinomas from Thailand

[摘要] Hepatocellular carcinoma (HCC) may develop according to two major pathways, one involving HBV infection andTP53mutation and the other characterized by HCV infection andCTNNB1mutation. We have investigated HBV/HCV infections andTP53/CTNNB1mutations in 26 HCC patients from Thailand. HBV DNA (genotype B or C) was detected in 19 (73%) of the cases, including 5 occult infections and 3 coinfections with HCV.TP53andCTNNB1mutations were not mutually exclusive, and most ofTP53mutations wereR249S, suggesting a significant impact of aflatoxin-induced mutagenesis in HCC development.

[学科分类] 传染病学