Effects of In vitro hemodilution, hypothermia and rFVIIa addition on coagulation in human blood

[摘要] Coagulopathy can occur after hemorrhage, trauma and resuscitation, and has been associated with dilution of coagulation factors and hypothermia. Recombinant activated Factor VII (rFVIIa) has been used, often as a last resort, to improve hemostasis in trauma/hemorrhage patients with coagulopathy. The aim of this study was to further characterize the effects of rFVIIa on various coagulation parameters and the influence of temperature and hemodilution.

[学科分类] 外科医学

[关键词] TEG;thrombin generation;PT;aPTT