HPV Prevalence and Concordance in the Cervix and Oral Cavityof Pregnant Women

[摘要] Objectives:This investigation examined human papillomavirus (HPV) in pregnant women in order tocharacterize viral prevalence, types and concordance between infection in the cervix and in the oral cavity.Methods:A total of 577 pregnant women seeking routine obstetric care were evaluated for HPV infection intheir cervix during gestation and immediately before delivery, and in the oral cavity during gestation. Malepartners present during the gestational clinic visit also provided a specimen from their oral cavity. HPVassessment was performed by PCR, dot blot hybridization and DNA sequencing. A sexual and healthquestionnaire was completed by the pregnant women.Results:HPV prevalence in women was 29% in the cervix and 2.4% in the oral cavity. Among those with bothgestational and delivery specimens, 35% were infected at least once and 20% had infection at both intervals. Atdelivery, 68% of infected women had an oncogenic HPV type in the cervix. There was no type-specific HPVconcordance between the two cervical specimens, nor cervical and oral results in women, nor with cervical andoral findings between partners.Conclusion:The lack of association in HPV positivity and types between the cervix and oral cavity in thesewomen suggests that self-inoculation is uncommon. This source of infection does not appear to be from oralcontact with a current male partner, since there also was no concordance between partners. These resultssuggest either other modes of HPV transmission or differences in susceptibility to HPV infection or its clearancein the oral cavity and genital mucosa.

[学科分类] 妇产科学