Chlamydia trachomatisVaccine Research through the Years

[摘要] Chlamydia trachomatisis a Gram-negative obligate intracellular bacterium. It is the leading cause of bacterial sexual transmitted infections (STIs). World Health Organization figures estimated that over 90 million new cases of genitalC. trachomatisinfections occur worldwide each year. A vaccination program is considered to be the best approach to reduce the prevalence ofC. trachomatisinfections, as it would be much cheaper and have a greater impact on controllingC. trachomatisinfections worldwide rather than a screening program or treating infections with antibiotics. Currently, there are no vaccines available which effectively protect against aC. trachomatisgenital infection despite the many efforts that have been made throughout the years. In this paper, the many attempts to develop a protective vaccine against a genitalC. trachomatisinfection will be reviewed.

[学科分类] 妇产科学