Human Papillomavirus Cervical Infection and Associated Risk Factors in a Region of Argentina With a High Incidence of Cervical Carcinoma

[摘要] Objective:To assess the prevalence and potential riskfactors associated with human papillomavirus (HPV) cervical infection amongwomen residing in a region of northeastern Argentina with a high incidence ofcervical cancer.Methods:A case-control study of 330 women participating in a cervicalcytological screening program conducted in Posadas city, Misiones, Argentina,from February 1997 to November 1998 was carried out. Standardizedquestionnaires were administered, and clinical examination includingcolposcopy was performed. Fresh endocervical specimens for HPV DNAdetection by generic polymerase chain reaction were collected and the productstyped by dot-blot hybridization.Results:Human papillomavirus DNA was found in 61%of samples analyzed (185/301). Samples with normal cytology had a 43% infection rate (85/199), while those classified as low-grade squamous intraepithelial lesion, high-grade squamous intraepithelial lesion, and invasive cervical carcinoma had an infection rate of 96% (53/55), 100% (29/29), and 100% (18/18), respectively. Human papillomavirus typing showed a 64% (118/185) prevalence of type 16 among all the infected population analyzed; type 16 was detected among 49% (42/85) of infected samples with normal.cytology and in an average of 74% (74/100) with abnormal cytology. Sexual behavior, residence in southern Paraguay, and history of a previous sexually transmitted diseases were the main risk factors associated with high-grade cervical lesions.Conclusions:An elevated prevalence of HPV infection was detected in this population, which also has a high incidence of cervical cancer. The broad distribution of high-risk HPV type 16 in women with normal cytology and colposcopy suggests that viral infection is an important determinant of regional cancer incidence. Infect. Dis. Obstet. Gynecol. 7:237–243, 1999.

[学科分类] 妇产科学