Prophylactic Antibiotics for Suction Curettage in Incomplete Abortion

[摘要] Objective:The purpose of this study was to investigate the efficacy of 200 mg of prophylacticdoxycycline in preventing pelvic infection after curettage for spontaneous (incomplete) abortion.Methods:A randomized, prospective, double-blinded study was carried out involving 300 womenwith an incomplete abortion who were given either placebo or 200 mg of doxycycline orally 30–60min prior to curettage. A hematocrit, WBC count, pregnancy test, syphilis serology,Neisseriagonorrhoeaeculture, and Micro Trak (monoclonal antibody test, Syba, San Jose, CA) forChlamydiatrachomatiswere performed. The patients were scheduled for follow-up 2 weeks later. Antibioticadministration for any reason as well as the postoperative infection rate in these women wasassessed.Results:Eleven women were excluded from analysis, leaving 289 evaluable.N. gonorrhoeaewasisolated from 6 (2%) women andC. trachomatisfrom 8 (3%) women, and the syphilis serology wasserofast in 4 (1%) women. Endometritis complicated the procedure in 4 women who receivedplacebo and in 1 woman who received doxycycline (P= 0.22).Conclusion:Prophylactic doxycycline is not effective in preventing pelvic infection after curettagefor spontaneous (incomplete) abortion.

[学科分类] 妇产科学