The Pharmacokinetics of Once-Daily Dosing WithGentamicin in Women WithPostpartum Endometritis

[摘要] Objective:To evaluate the pharmacokinetics and cost of once-daily dosing with gentamicin inwomen with postpartum endometritis.Methods:Gentamicin in a single daily dose of 4.5 mg/kg was administered intravenously to10women with postpartum endometritis. Peak and trough gentamicin levels were measured, andnephrotoxicity and clinical ototoxicity were monitored. Pharmacokinetic data were analyzed, anda cost analysis of once-daily gentamicin administration was performed.Results:The mean elimination conslant was 0.105 ± 0.008 L/h, and the mean volume of distributionwas 0.34 ± 0.07 L/kg. Mean peak gentamicin levels exceeded 11 mg/L, and all trough levelswere <0.3 mg/L. Cost savings of 44% were achieved with once-daily dosing of gentamicin, comparedwith traditional thrice-daily dosing.Conclusions:Once-daily dosing with gentamicin in women with postpartum endometritis achievestherapeutic peak levels without drug accumulation. Substantial cost savings are realized with thisdosing regimen.

[学科分类] 妇产科学