Cutaneous Anergy in Pregnant and NonpregnantWomen With Human Immunodeficiency Virus

[摘要] Objective:To determine the prevalence of cutaneous anergy in pregnant and nonpregnant womenwho are seropositive for human immunodeficiency virus.Methods and materials:The medical records of 159 women seropositive for human immunodeficiencyvirus were reviewed. Demographic characteristics and tuberculin skin test results wereabstracted from the chart. Tuberculin skin testing was performed by the Mantoux method (5tuberculin units of purified protein derivative injected intradermally). Anergy testing was performedusing any two of the three following antigens; tetanus toxoid, mumps, orCandidaskin testantigen. A positive tuberculin test was defined as induration of 5 mm or more, and a positive test forthe other antigens was defined as any amount of induration over the skin test area. Anergy wasdefined as any amount of induration to the other antigens. A CD4+T lymphocyte count wasobtained at the time of skin testing. Continuous variables were analyzed using the Mann Whitney—Utest. Categorical data were analyzed with the chi-square or Fisher's exact test as appropriate.A two-tailedPvalue <0.05 was considered significant.Results:There were 102 nonpregnant and 57 pregnant women who returned to have their skintest results read. There was no significant difference in the prevalence of positive, negative oranergic skin test results between groups. The CD4+T lymphocyte count (mean ± standard deviation)in patients with anergic results was similar between pregnant (375 ± 256/mm3) and nonpregnant(358 ± 305/mm3) women (P= 0.64).Conclusion:The prevalence of cutaneous anergy is similar among pregnant and nonpregnantwomen seropositive for human immunodeficiency virus.

[学科分类] 妇产科学