Female Genital Tract Bacterial Coisolates WithCandida albicansin Patients Without Clinical Vaginitis

[摘要] Objective:In vitro,Candida albicanshas demonstrated the ability to inhibit replication of selectedbacteria. Little information exists on the impact ofC. albicanson the vaginal bacterial flora in vivo.The purpose of this study is to identify the coexisting bacterial flora whenC. albicansis isolated fromvaginal cultures submitted to a hospital-based testing facility for reasons other than vulvovaginitis.Methodology:All specimens (240) received from ambulatory care clinics over a six-month periodwere cultured for aerobic and anaerobic bacteria andCandidaspecies. Those specimens submittedfor cervicitis, vaginitis, or vaginal discharge and those from which yeasts other thanC. albicanswere isolated were eliminated. To control for sample biases, a subgroup composed of all pregnantwomen for whom cultures were done as screening procedures was similarly studied. Chi-squareanalyses, comparing the prevalence of individual bacteria isolated with and without the presence ofC. albicans, were done for all study populations using SPSS for Windows software (1994).Results:Two hundred and forty consecutive specimens were bacteriologically analyzed. Of the220 vaginal samples used in the study,C. albicanswas isolated in 44 instances (20%). Neither thepresence of the lactobacilli nor the presence ofGardnerella vaginalismarkedly influenced the isolationrate ofC. albicans. The group B streptococci had a greater probability of coisolation whenC. albicanswas present (27.3%) verses 16%), but this was not statistically significant (P< 0.8).Dissociation between the presence ofC. albicansand the coisolation ofPeptostreptococcusspeciesand anaerobic gram-positive cocci and/or bacilli was noted (P< 0.0819). while the incidence ofgram-positive aerobic bacilli was reduced in the presence ofC. albicans(30/176 [17.1%] versus 6/44[13.6%]), this reduced incidence was not statistically significant. Isolation data of the subgroup ofpregnant women supported these observations.Conclusion:Within the limitations of the study, statistically, the data suggests that an inverserelationship exists between the presence ofC. albicansand recovery ofPeptostreptococcusand anaerobicgram-positive cocci and bacilli.

[学科分类] 妇产科学