Studies on the Pathogenicity of Anaerobes, EspeciallyPrevotella bivia, in a Rat Pyometra Model

[摘要] Objective: Prevotella biviais one of the anaerobic bacteria that resides in the flora of the femalegenital tract. We studied the pathogenicity ofP. biviain a rat pyometra model.Methods:The experimental animial (rat) model of pyometra was developed to investigate thepathogenicity ofP. biviain a rat pyometra model.Results:In the groups inoculated with aerobes alone, the infection rate was 10% (1/10) in theStaphylococcus aureus- orStaphylococcus agalactiae-inoculated group and 20% (2/10) in theEscherichia coli-inoculated group. Infection Was not established in the groups inoculated with anaerobesalone. High infection rates were observed in all the mixed-infection groups. In theS. agalactiae- andBacteroides fragilis-,S. agalactiae- andP. bivia -, E. coli-andB. fragilis-, andE. coli- andP. biviai- inoculatedgroups, an infection rate of 100% (10/10) was demonstrated. The efficacy of antibioticssuch as flomoxef (FMOX) could be determined using a rat pyometra model. In relation to thealteration of vaginal microbial flora during the menstrual cycle, estrogen increased the growth ofP. bivia.Conclusion:Mixture of aerobic bacteria andP. biviaincreased the pathogenicity ofP. bivia.Estrogen would be useful for raising up the inflammatory change of the uterus in experimentalmodels of genital tract infection due toP. bivia.

[学科分类] 妇产科学