Comparison of Short Vs. Long Half-Life Single-Dose Prophylactic Antibiotics for Cesarean Section

[摘要] Objective:Numerous studies demonstrate the efficacy of antibiotic prophylaxis for reducing postcesareansection infectious morbidity. The duration of therapy, however, remains controversial.Cost containment measures and the ease of single dosing have led to the introduction of “extended”half-life agents for cesarean-section chemoprophylaxis. We tested the hypothesis that there was nodifference in efficacy between a single dose of a short half-life agent (cefoxitin) and a longer half-lifeagent (cefotetan).Methods:A prospective, double-blind trial of 375 non-elective cesarean-section cases was carriedout. Study antibiotics (2 g) were administered intravenously (IV) at cord clamping only.Results:Demographic and clinical variables between the 2 study groups were similar. No significantdifferences were noted in major or minor morbidity or in infectious morbidities for patientsreceiving the 2 prophylactic regimens. The occurrence of postoperative endometritis was likewisesimilar for the subjects receiving cefoxitin (10%) and cefotetan (15%). When cases whose surgerylasted >60 min were evaluated separately, no differences in outcomes between the 2 groups wereidentifiedConclusions:These findings confirm our hypothesis that the half-life difference between these 2agents does not impact on single-dose Prophylactic efficacy in cesarean section.

[学科分类] 妇产科学