Treatment of Sporadic Acute Puerperal Mastitis

[摘要] Objective:The purposes of this study were to compare the efficacy of amoxicillin and cephradine for thetreatment of sporadic acute puerperal mastitis (SAPM) and to evaluate the microbiology and clinicalparameters of this infection.Methods:We conducted a prospective, randomized, single-blinded study comparing amoxicillin, 500 mgorally q 8 h for 7 days, and cephradine, 500 mg orally q 6 h for 7 days. The diagnostic criteria for SAPMincluded a temperature of ≥37.56℃ (≥99.6℉) and erythema and tenderness of the breast(s).Results:Twenty-seven consecutive outpatients with SAPM were evaluated for admission to the study,and 25 of these were enrolled. The mean temperature at enrollment was 38.17℃ (100.7℉), with a meanWBC count of 11,440/μl. The most frequent bacterial isolates from expressed milk wereStaphylococcus aureus(7), staphylococcal species (coagulase negative) (8), and α-hemolytic streptococci (4). There wereno significant differences between the 2 antibiotic regimens in cure rate, mean days to resolution ofsymptoms, or recurrence within 30 days. Both of the treatment failures and 1 of the 3 recurrences within30 days were amoxicillin-treated patients whose cultures grewS. aureus.Conclusions:Oral amoxicillin and cephradine appear equally effective in the treatment of SAPM. Staphylococciwere the most frequent isolates from the milk of women with mastitis.

[学科分类] 妇产科学