Azithromycin (Zithromax®)

[摘要] Azithromycin (Zithromax®, Pfizer, Inc., New York, NY) is a 15-membered-ring macrolide andthe first azalide antibiotic. It is distinguished from other macrolides by its rapid and extensivepenetration into intracellular and interstitial tissue compartments, accompanied by prolongedtissue and serum half-lives. Azithromycin shares the gram-positive activity of erythromycin butis more potent against gram-negative organisms. For urethritis and cervicitis caused byChlamydia trachomatis, azithromycin is effective and well tolerated in a single dose of 1 g, a regimenrecommended by the CDC. A 5-day dosage regimen is available for the treatment of community-acquiredrespiratory-tract and skin and skin-structure infections caused by susceptible organisms.Azithromycin provides short-duration, high-compliance, cost-effective regimens that should improveoutcomes.

[学科分类] 妇产科学