Ex Vivo Human Placental Transfer of Trovafloxacin

[摘要] Objective:The purpose of this study was to determine the ex vivo human placental transfer oftrovafloxacin from the maternal circulation to the fetal circulation.Methods:Six placentas from uncomplicated, term, vaginal or cesarean deliveries were studiedusing the ex vivo isolated cotyledon perfusion chamber;C14-antipyrine was used as a referencecompound to determine the clearance index (CI) of trovafloxacin.Results:The CI of trovafloxacin was 0.19 ± 0.13 at a mean trough concentration of 1.38 ± 0.22μg/ml and 0.16 ± 0.10 at a mean peak concentration of 7.48 ± 2.3 μg/ml as determined by our newlydeveloped high-pressure liquid chromatographic assay. Tissue concentration did not exceed maternalconcentration, and there was little or no accumulation when the perfusion system was closed for1 hr.Conclusions:Trovafloxacin crosses the placenta by simple diffusion and does not accumulate inthe media to any extent, nor does it bind to tissue or accumulate in the placenta. Infect. Dis. Obstet.Gynecol. 8:228–229, 2000.

[学科分类] 妇产科学