Immunotherapy of Gynaecological High-Risk HumanPapilloma Virus Infection With HumanLeukocyte Ultrafiltrate

[摘要] Objective:In this preliminary presentation the outcome of women following systemic treatment ofcervical human papilloma virus (HPV) with a leukocyte ultrafiltrate is reported.Methods:Cervical brush specimens of 819 women with low-grade CIN-1 were evaluated forHPV infection. HPV-positive patients were treated either by cone biopsy because of suspiciouseolposeopy or by antibiotics for symptoms of bacterial cervieitis. The remaining women wereconsidered as asymptomatic carriers of HPV and underwent systemic therapy by a human leukocyteultrafiltrate in a dosage of 5 IE, 6 times in the first 2 weeks, and additionally as a single doseat weeks 4, 6, 8 and 10.Results:The leukocyte ultrafiltrate was administered to 97 HPV-positive women. In follow-up88.7% were HPV negative at week 6; the remaining 11 women were tested negative after completionof a second course of therapy.Conclusions:These preliminary data on the successful treatment of HPV infection by a leukocyteultrafiltrate are very promising but have to be supported by additional research. Infect. Dis. Obstet.Gynecol. 8:120–123, 2000.

[学科分类] 妇产科学