In Vitro Inhibition of Commercial Douche ProductsAgainst Vaginal Microflora

[摘要] Recently, vaginal douching has been associated with many health risks in women. The aim of thisstudy was to analyze the effect of commercial douche products against various vaginal microorganisms,including lactobacilli. Seven commercial douches were tested against eightLactobacillusclinical isolates and three type strains from the American Type Culture Collection. BV-associatedbacteria included six strains of five genera:Gardnerella, Mobiluncus, Mycoplasma, Peptostreptococcus,andUreaplasma. Two isolates of group BStreptococcus, and three species ofCandidawere alsotested. The minimal inhibition concentrations and minimal contact times for these products againstvaginal microorganisms were determined in broth cultures. Four antiseptic-containing doucheproducts showed a strong inhibitory effect against all vaginal microorganisms tested with a shortcontact time (less than 1 min). Three vinegar-containing douche products selectively inhibited vaginalpathogens associated with bacterial vaginosis, group B streptococcal vaginitis, and candidiasis, but notlactobacilli. The antimicrobial effects of the commercial douche products varied among different brandsand microbial species tested. Infect. Dis. Obstet. Gynecol. 8:99–104, 2000.

[学科分类] 妇产科学