IL-1b, IL-6 and IL-8 Levels in Gyneco-Obstetric Infections

[摘要] Objective.During pregnancy cytokines and inflammatory mediators stimulate the expression of prostaglandin, the levels of which determine the onset of labor. The aim of this work was to study interleukin IL-1β, IL-6 and IL-8 levels in the vaginal discharge, serum and urine of pregnant women with genitourinary infection before and after specific treatment. One hundred and fifty-one patients were studied during the second or third trimester of their pregnancy.Methods.The selected patients were: healthy or control group (n= 52), those with bacterial vaginosis (n= 47), those with vaginitis (n= 37), those with asymptomatic urinary infection (n= 15) and post-treatment. The level of cytokines was assayed by ELISA test. The Mann–Whitney U-test was used for statistical analysis.Results.The IL-1βlevels in vaginal discharge were: control 103.5 ± 24.2 pg/ml, bacterial vaginosis 1030 ± 59.5, vaginitis749.14 ± 66.7l (p< 0.0001), post-treatment 101.4 ± 28.7. IL-6 values were similar in both control and infected groups, and there were no patients with chorioamnionitis. In vaginal discharge IL-6: control 14.2 ± 3.9 pg/ml, bacterial vaginosis 13.2 ±3.8, vaginitis 13 ±4.2. IL-8 levels were: control 1643 ± 130.3 pg/ml, bacterial vaginosis 2612.7 ±257.7, vaginitis 3437 ± 460 (p< 0.0001), post-treatment 1693 ±126.6. In urine the results were: control 40.2 ±17 pg/ml, asymptomatic urinary infection 1200.7 ±375 (p< 0.0001). In patients with therapeutic success both IL-1βand IL-8 returned to normal levels.Conclusions.Genitourinary infections induce a significant increase in IL-1βand IL-8 levels in vaginal secretions, and IL-8 in urine as well. Both cytokines could be useful as evolutive markers of infection.

[学科分类] 妇产科学