In VitroAnti-CandidaActivity of Lidocaine and Nitroglycerin: Alone and Combined

[摘要] The aim of this work was to study the anti-Candidaactivity of lidocaine and nitroglycerin alone and in combination. TenCandidastrains were included, corresponding to 1 collection type strain (ATCC 10231) and 9 clinical isolates: 4C. albicans, 2C. glabrata, 1C. tropicalis, 1C. krusei, and 1C. parapsilosis. The CLSI reference M27-A3 micromethod was used to determine the anti-Candidaactivity of the drugs alone; minimal inhibitory and lethal concentrations were determined. The classic checkboard technique was used to determine the activity of combined drugs. Lidocaine fungicidal effect was dosedependent. Nitroglycerin exhibited a higher effect. The drugs combination resulted in a reduction of the inhibitory concentration, corresponding to an additive effect. In conclusion, both drugs exhibited an interesting anti-Candidaactivity. The combination of lidocaine with nitroglycerin was shown to have an additive effect againstCandidaspp., predicting the interest to include, in the future, these drugs in a new delivery system for the treatment of mucocutaneous candidosis.

[学科分类] 妇产科学