Case–Control Study of Vulvar Vestibulitis Risk Associated WithGenital Infections

[摘要] Objective:To evaluate the risk of vulvar vestibulitis syndrome (VVS) associated with genital infections in acase–control study.Methods:Diagnosed cases with VVS (n= 69) and age-frequency-matched healthy controls (n= 65) wereenrolled from gynecology clinics in a university medical hospital during 1999. They were compared for potentialrisk factors and symptoms of disease.Results:VVS cases had a significantly higher risk of physician-reported bacterial vaginosis (BV) (odds ratio,OR = 9.4), Candida albicans (OR = 5.7), pelvic inflammatory disease (PID) (OR = 11.2), trichomoniasis(OR = 20.6), and vulvar dysplasia (OR = l5.7) but no risk associated with human papillomavirus (HPV), ASCUS,cervical dysplasia, genital warts, chlamydia, genital herpes or gonorrhea. Genital symptoms reported significantlymore often with VVS included vulvar burning (91 vs. 12%), dyspareunia (81 vs. 15%), vulvar itching (68 vs. 23%)and dysuria (54 vs. 19%) (p< 0.0001).Conclusion: A history of genital infections is associated with an increased risk of VVS. Long-term follow-upcase–control studies are needed to elucidate etiologic mechanisms, methods for prevention and effectivetreatment.

[学科分类] 妇产科学