Antimicrobial Susceptibility of Gram-Negative UropathogensIsolated From Obstetric Patients

[摘要] Objective:To evaluate the antimicrobial susceptibility of Gram-negative uropathogens isolated from pregnantwomen.Methods:We performed a snapshot cohort study of women receiving care in the University of Florida prenatalclinics duringMarch 2000. Subjects with asymptomatic bacteriuria or cystitis were identified and the antimicrobialsusceptibility of each pathogen was recorded. Data were analyzed using chi-square, Fisher's exact test andninety-five percent confidence intervals, as appropriate.Results:Ninety-five positive cultures were identified. Isolates were more often susceptible to trimethoprimsulfamethoxazole(TMP-SMX) (87%) and nitrofurantoin (89%) than to ampicillin (72%) (p< 0.03). Escherichia coliaccounted for 71 (75%) cases and was more often susceptible to nitrofurantoin (100%) than to TMP-SMX (87%)(p< 0.01). Proteus isolates were all susceptible to TMP-SMX and resistant to nitrofurantoin (p< 0.01).Conclusions:Both TMP-SMX and nitrofurantoin are superior to ampicillin for empiric treatment of lower urinarytract infection in pregnant women. Nitrofurantoin is superior to TMP-SMX for treatment of infections caused byE. coli. For suspected or confirmed cases caused byProteusorganisms, TMP-SMX is the preferred agent.

[学科分类] 妇产科学