Chemical Constituents of the Aerial Parts of Scoparia dulcis and Anti-cancer, Anti-inflammatory Activities
[摘要] In Vietnam, the medicinal plant Scoparia dulcis is used for the treatment of bronchitis, gastric disorders, antidiabetes, hypertension, hepatitis etc. In this paper, experiments was designed to evaluate in vitro anticancer and anti-inflammatory activities and isolate phytochemicals from methanol extracts of Scoparia dulcis whole plants. The chemical investigation of methanol fraction of Scoparia dulcis led to the isolation of benzoxazinone (1), phenylethanoid (2), flavone (3), and lignan (4) glycosides. The bioactivity results indicated that crude ethanol and ethyl acetate extracts had potent cytotoxic activity toward the HepG2 cancer cell with IC50 of 47.03 μg/mL and 36.04 μg/mL, respectively. Interestingly, crude ethanol and ethyl acetate extracts had the NO inhibitory activity, with inhibition of 56.9 % or 74.7 % at 30 μg/mL and 97.3% or 82.9 % at 100 μg/mL, respectively. In addition, the hexane extract at concentrations of 100 μg/ml demonstrated anti-inflammatory activity through the inhibition of nitric oxide production of 76.7%.
[发布日期] [发布机构] Nguyen Thong High School, Vinh Long Province, Viet Nam^1;Faculty of Natural Sciences, Tien Giang University, Tien Giang Province, Viet Nam^2;NTT Hi-Tech Institute, Nguyen Tat Thanh University, Ho Chi Minh City, Viet Nam^3;Faculty of Chemical Engineering and Food Technology, Nguyen Tat Thanh University, Ho Chi Minh City, Viet Nam^4;Institute of Applied Materials Science, Vietnam Academy of Science and Technology, Ho Chi Minh City, Viet Nam^5;Graduate University of Science and Technology, Vietnam Academy of Science and Technology, Ha Noi, Viet Nam^6
[效力级别] 材料工程 [学科分类]
[关键词] Anti-inflammatory activity;Chemical constituents;Cytotoxic activities;Medicinal plants;Methanol extract;Methanol fraction;No inhibitory activities;Phytochemicals [时效性]
