Two Flavonoids From Stem Bark of Casimiroa edulis and Their Antidiabetic and Antioxidant Activities

[摘要] Casimiroa edulis Llave et Lex (Rutacae), popularly known as white sapote. The main aim of this study is to isolate and investigate the bioassay of the stem bark of Casimiroa edulis. Two flavonoids were isolated from the methanolic fraction of the stem bark of Casimiroa edulis. The isolated compounds can be identified as 6,7-dimethoxyflavone (1) and 5,6,2′-trimethoxyflavone (2) by using advance spectroscopic methods, including FT-IR, UV, 1D NMR, 2D NMR. Compounds 1 and 2 were evaluated for their antidiabetic and antioxidant activities. The result revealed that the two compounds did not have antidiabetic activity and antioxidant activity. This is the first phytochemical study of 6,7-dimethoxyflavone from the genus Casimiroa.

[发布机构] Fac. of Science and Technology, Universitas Airlangga, Jl. Mulyorejo, Surabaya, Indonesia^1;Dept. of Chemistry, Taunggyi University, Shan State, Myanmar^2;Dept. of Chemistry, Fac. of Science and Technology, Universitas Airlangga, Jl. Mulyorejo, Surabaya, Indonesia^3;Fac. of Pharmacy, Meijo University, 150 Yagotoyama, Tempaku; 468-8503, Japan^4

[效力级别] 化学 [学科分类] 生物科学（综合）

[关键词] Anti diabetics;Anti-oxidant activities;Antidiabetic activity;Isolated compounds;Phytochemical;Rutacae;Spectroscopic method;Stem bark