Chromanone Acid Derivatives from the Stem Bark of Calophyllum incrassatum

[摘要] Two chromanone acid derivatives, calofolic acid B (1) and apetalic acid (2) were isolated from the stem bark of Calophyllum incrassatum. The structures of both compounds were elucidated by UV, IR, HRESIMS, 1D and 2D NMR spectroscopies and comparison of their data with literatures. Compounds 1-2 were evaluated for their cytotoxic activity against P-388 cells, compound (1) showing value IC50 1.14 μg/mL.

[发布机构] Natural Products Chemistry Research Group, Organic Chemistry Division, Department of Chemistry, Surabaya, Indonesia^1

[效力级别] 化学 [学科分类] 生物科学（综合）

[关键词] 1D and 2D NMR spectroscopies;Acid derivative;Calophyllum incrassatum;Cytotoxic activities;Stem bark