First Order Kinetics of Salicylamide Release from κ-Carrageenan Hard Shell Capsules in Comparison with Gelatin

[摘要] Drug delivery material is one of popular topics of research in this era because the developmet of medicines require a good carrier of the drugs produced and synthesized. However, recent produced capsules were made from animal's extract such as bone or skin that could not be suitable for everyone, especially the ones with animal's meat intolerant. Hard shell capsules were produced from κ-carrageenan-alginate (CA) and κ-carrageenan-starch (CS) of cassava. First order kinetics of salicylamide released from hard shell capsules of CA and CS were determined using the Noyes-Whitney modification equations. The optimum k1 of gelatin capsules calculated was 0.0108 ppm/min at pH 6.8, CA was 0.0.0493 ppm/min, and CS was 0.0237 ppm/min. This means that CA and CS could be recommended. Further development is needed to produce the best CA and CS capsules as drug delivery material.

[发布机构] Department of Chemistry, Faculty of Science and Technology, Universitas Airlangga, Surabaya; 60115, Indonesia^1;Deparment of Pharmaceutics, Faculty of Pharmacy, Universitas Airlangga, Surabaya; 60115, Indonesia^2;Medicinal Chemistry and Natural Product Research Group, School of Pharmacy and Biomolecular Science, Liverpool John Moores University, Byrom Street, Liverpool; L33AF, United Kingdom^3

[效力级别] 化学 [学科分类] 生物科学（综合）

[关键词] Drug delivery materials;First order kinetics;Kappa carrageenan;Salicylamides;Whitney