Saponin, Polyphenol, Flavonoid content and α-glucosidase Inhibitory Activity, Antioxidant Potential of Launaea sarmentosa Leaves grown in Ben Tre province, Vietnam

[摘要] Launaea sarmentosa (Willd) Schultz-Bip.ex Kuntze, a creeping herb, belongs to family Asteraceae. It is distributed in sandy coasts of India, Sri Lanka, Malaysia, East Africa and Vietnam. In Vietnamese folk medicine, whole plant possess tonic, soporific, diuretic, laxative properties and the roots are used to benefit milk for mothers after childbirth, instead of Lactuca indica. Up to now, the phytochemicals and bioactivities of this plant are not yet been examined. The present study was designed to investigate the saponin, polyphenol and flavonoid contents as well as α-glucosidase inhibitory and antioxidant activities of the leaves of L. sarmentosa. Preliminary phytochemical screening of this plant were found to give positive reactions for flavonoid, saponin, alkaloid, tannin, and steroid compounds. The result of quantitative determination showed that the leaves contains high amount of polyphenol compounds (290.90 mg GAEs/g extract), lower amount of flavonoids (85.47 mg QEs/g extract) and the saponin content was found to be 10.8 % (per dry weight). As expected, the ethanol extract had a antioxidant potential with IC50 value of 24.15 μg/mL in DPPH experiment, compared to that of vitamin C. Meanwhile, the α-glucosidase inhibitory assay showed inhibited enzyme activity with IC50 value of 67.09 μg/ml.

[发布机构] Institute of Applied Materials Science, Vietnam Academy of Science and Technology, Ho Chi Minh city, Viet Nam^1;Faculty of Chemical Engineering and Food Technology, Nguyen Tat Thanh University, Ho Chi Minh City, Viet Nam^2;Graduate University of Science and Technology, Vietnam Academy of Science and Technology, Ha Noi, Viet Nam^3;Vietnam Sarmentosa Joint Stock Company, Ben Tre Province, Viet Nam^4;Faculty of Natural Sciences, Tien Giang University, Tien Giang Province, Viet Nam^5;College of Natural Sciences, Can Tho Univesity, Can Tho City, Viet Nam^6;NTT Hi-Tech Institute, Nguyen Tat Thanh University, Ho Chi Minh City, Viet Nam^7

[效力级别] 机械制造

[关键词] Alpha glucosidase;Anti-oxidant activities;Antioxidant potential;Ethanol extract;Flavonoid content;Inhibitory activity;Phytochemicals;Quantitative determinations