Control of cell differentiation in lizard epidermis in vitro☆
[摘要] Theperiodicskin-sheddingoflizardsinvolvesthelossandreplacementofepidermalgenerations.Agenerationconsistsofseveralstrata,eachstratumcomprisingaspecificcelltype.Thecelltypesarederivedfromamorphologicallyhomogeneousgerminal-celllayer.Piecesofintactskin(epidermisplusdermis)continuetoproduceepidermalgenerationsforperiodsupto49daysinvitro.Thestructureofthesegenerationsisnotsignificantlydifferentfromthatformedinvivo.TreatmentwithEDTAeffectsdermoepidermalseparation.Whengrowninvitro,theintactisolatedepidermisshowsnormaldifferentiationandgenerationformation.Alterationsinintercellularrelationships,suchasoccurinregionsofcellmigrationorafterremovaloftheouterepidermallayers,areassociatedwithderangementofthenormalchangingpatternofcelldifferentiation.Theseobservationsindicatethatthecapacityforthecomplexchangingpatternofcelldifferentiationisintrinsictotheepidermis.Itissuggestedthatthepatternofdifferentiationisregulatedbyafeedbackmechanismeffectedviacommunicationbetweentheepidermalcellsofthedifferentstrata.
[发布日期] [发布机构]
[效力级别] [学科分类] 生物科学（综合）
[关键词] [时效性]
