Translational discrimination of ribosomal protein mRNAs in the early Drosophila embryo☆
[摘要] MostDrosophilamRNAsareactivelytranslatedintheearlyembryo,withtheexceptionofthepoorlytranslatedribosomalprotein(r-protein)mRNAs.Twopossiblemechanismsforthistranslationaldiscriminationweretested:(1)Translationofr-proteinmRNAsisdiscriminatedagainstbythelimitedactivityoftranslationalinitiationfactorsintheearlyembryoand(2)translationofr-proteinmRNAsisrepressedbytrans-actingfactorsthatreversiblybindthesemRNAs.Exogenouslyprovidedinitiationfactorspromotedpartialrecruitmentofr-proteinmRNAsintopolysomes,suggestingthatmodulationofinitiationfactoractivitymayplayaroleinthetranslationaldiscriminationofr-proteinmRNAsduringembryogenesis.Noevidenceforinvolvementofreversiblybindingtrans-actingfactorswasobtained,althoughtherearelimitationsintheinterpretationofthelatterexperiments.
[发布日期] [发布机构]
[效力级别] [学科分类] 生物科学（综合）
[关键词] [时效性]
