Muscle fibers from dysgenic mouse in vivo lack a surface component of peripheral couplings☆
[摘要] Wehavestudiedthestructureofdevelopingnormalanddysgenic(mdgmdg)mousemusclefibersinvivo,withspecialattentiontothecomponentsofthejunctionsbetweenthesarcoplasmicreticulumandeitherthesurfacemembraneorthetransversetubules.Triadsanddyadsarerareindysgenicmusclefibers,buthaveapparentlynormaldispositionoffeetandcalsequestrin.Peripheralcouplingsinnormaldevelopingmusclefibershavejunctionaltetradsintheirsurfacemembraneinassociationwiththejunctionfeet.Musclefibersindysgenicmicelackjunctionaltetrads.Thisprovidesindirectevidencefortheidentificationofthecomponentsofjunctionaltetradswithdihydropyridinereceptors,whichareknowntobeabsentindysgenicmusclefibers.
[发布日期] [发布机构]
[效力级别] [学科分类] 生物科学（综合）
[关键词] [时效性]
