Cell proliferation in embryonic mouse neural tube following urethane exposure☆
[摘要] Acomparativeautoradiographicstudyofthecellcycleinnormal10-daymouseembryosandinembryosexposedtourethaneshowedanincreaseof4.5hoursinthecycletimeoftheexperimentalgroup.Initiallyurethaneinterferedwiththemigrationofsomeunlabeledpremitoticnucleitothegerminalzone,resultinginextraventricularmitoses.Atransientincreaseinthemitoticindexandproportionofmetaphasessuggestedalengthenedmitotictimebutthiswasofbriefdurationandwouldnotcontributesignificantlytotheoverallincreasedcycletime.TheG2periodofcellswhichincorporatedthymidine-3HinthepresenceofurethanewassignificantlylengthenedasweretheSandG1periodsandsomeinjuredcellsdiedininterphaseormitosis.Thenewlengthenedgenerationtimeofembryoneuraltubesexposedtourethaneresemblesthatofolder,11-dayembryos.Thissuggeststhepossibilitythatcellswithashortcyclemaybepreferentiallykilledbyurethane,leavingthedeterminationofmeancycletimetomoredifferentiatedcells.
[发布日期] [发布机构]
[效力级别] [学科分类] 生物科学（综合）
[关键词] [时效性]
