Human teratoma cells share antigens with mouse teratoma cells☆
[摘要] Themouseteratocarcinomacellline402AXisknowntoexpresssurfaceantigens[hereaftercalledteratoma-definedantigen(s)]sharedwithearlymouseembryosandsomeothermurinecelllines,asdetectedbyanabsorbedrabbitantiserum.Asgaugedbyimmunofluorescence,humanteratocarcinomacells(tera2)followingneuraminidasetreatmentdisplayantigen(s)cross-reactivewithmouseteratoma-definedantigens.Onthehumantumorcellstheteratoma-definedantigen(s)isdensitydependent,beingpresentonsubconfluentcultures,butabsentonconfluentcultures.Neuraminidase-treatedcontrolsubconfluenthumanfibroblastsarenonreactivewiththeantiserum.Serafromsomehumanpatientspresentingwithteratocarcinoma,absorbedonnormalmousetissuetoremovethenonspecifichetero-anti-speciesantibodies,showanti-mouseteratomareactivitybyimmunofluorescenceandmicrocytotoxicity.Serafromage-andsex-matchedindividualswithnonteratomatumorsarenonreactivewiththemouseteratomacells.Theantigenicdeterminant(s)detectedbythehumanteratomaseraco-capswithH-2antigensonthemousemastocytomalineP815,asdotherabbitantiserum-definedteratomaantigens.Thesedatasuggestthathumanandmouseteratomassharecommonantigens,andthattheseantigensmaybeintegrallyrelatedtothemajorhistocompatibilityantigensinbothspecies.
[发布日期] [发布机构]
[效力级别] [学科分类] 生物科学（综合）
[关键词] [时效性]
