Studies of l(3)c43hs1 a polyphasic, temperature-sensitive mutant of Drosophila melanogaster with a variety of imaginal disc defects☆

[摘要] Theheat-sensitive,lethalmutationl(3)c43hs1(3–49.0)produceswidevarietyofdefectsintheimaginaldiscsofDrosophilamelanogaster.Atpermissivetemperatures(20°Corlower),homozygotesareviable,butsterile.At22°C,lethalityoccursduringthelatepupalstage,andat25°Corhigher,lethalityoccursduringthethirdlarvalinstar.Theimaginal-discabnormalitiesobservedafterexposuretorestrictivetemperaturesinclude:deficienciesofheadstructures,duplicationsanddeficienciesoftheantenna,ahomeotictransformationofthearistatotarsus,duplicationsanddeficienciesofwingandhalterestructures,differentiationofamorphouscuticularmaterialinthewingblade,anincreaseinthenumberofsex-combteeth,anddisruptionofthenormalsegmentationofthetarsus.Exposureto27°Cfor24hratdifferenttimesinthelifecyclerevealedthateachofthesedefectshasacharacteristictemperature-sensitiveperiod(TSP)duringthelarvalstages.InjectionofwingdiscsbeforeandaftertheirTSPshowedthatthemutationisexpressedautonomously.Theseresultsarediscussedinrelationtotherolethatthel(3)c43+geneplaysinthedevelopmentofimaginaldiscs.

[学科分类] 生物科学（综合）