Genetic mosaics of the rudimentary locus of Drosophila melanogaster: A genetical investigation into the physiology of pyrimidine synthesis☆
[摘要] Geneticmosaicshavebeenutilizedtoinvestigateeachofthethreepleiotropiceffectswhichresultfrommutationoftherudimentarylocus.Thewingabnormalityresultsfromarequirementforendogenouspyrimidinesynthesiswithinthewingimaginaldiskitself.Mosaicanalysisindicatesthedefectinthewingcanberescuedbypyrimidinesynthesisanyplacewithintheimaginaldiskandthatnomorethan10%ofthecellsofthediskneedbegeneticallycapableofproducingpyrimidines.Thisrequirementforendogenoussynthesisisprobablytheresultofareductionorcompleteeliminationofpyrimidineuptakeataparticularstageduringdevelopment.Ovarytransplantationsindicatethatthesterilityofhomozygousrudimentaryfemalesresultsfromarequirementforpyrimidinesynthesiswithintheovaryitself,andmosaicanalysisoftheauxotrophicphenotypeindicatesthatsurvivaloflarvaeonpyrimidine-freemediumdependsonpyrimidinesynthesiswithinavarietyofdifferenttissues.
[发布日期] [发布机构]
[效力级别] [学科分类] 生物科学（综合）
[关键词] [时效性]
