Neural influence on the postnatal changes in acetylcholine receptor distribution at nerve-muscle junctions in the mouse
[摘要] TheeffectofdenervationatdifferentstagesofdevelopmentonthepatternofjunctionalAChRmoleculeshasbeenexaminedinhindlimbmusclesofthemouseusingfluorescentα-bungarotoxin.DenervationatbirthleadsinafewdaystoamarkeddispersalofthejunctionalAChRcluster.ThemechanismofdispersalisunknownbutappearstobetooslowtobeexplainedbyfreediffusionofindividualAChRmolecules.Followingbirth,themorphologicalstabilityoftheclusterincreasessothatdenervationat2weeksofage,whenthematureformoftheclusterbeginstodevelop,leadstolittleincreaseinclustersize.Thechangesinthepatternofreceptorsseenwhenthenerveisintactarearrestedbydenervation.
[发布日期] [发布机构]
[效力级别] [学科分类] 生物科学（综合）
[关键词] [时效性]
