Multiple molecular forms of rat superior cervical ganglion acetylcholinesterase: Developmental aspects in primary cell culture and during postnatal maturation in vivo☆

[摘要] Fourmainmolecularformsofacetylcholinesterase(AChE)canbesolubilizedfromnewbornratsuperiorcervicalganglia(SCG),homogenizedinthepresenceofahigh-ionic-strength,detergent-containingmedium.Theseforms,respectivelyreferredtoas16,10,6.5,and4S,arecharacterizedbytheirsedimentationcoefficients.TheirrelativeproportionsinSCGarenotablydifferentinvivoduringpostnatalmaturation,andinculture.The16-SAChEappearstobemainlyneuronalinorigin,ismaintainedincultureindependentlyoforiginalpresynapticinvivoelements,anditscellularpoolisnotdepletedinthepresenceoftetrodotoxin(TTX).

[学科分类] 生物科学（综合）