Metallothionein mRNA expression in fetal mouse organs☆
[摘要] Theregulationofmetallothioneinbiosynthesisinmammaliandevelopmentwasinvestigatedbyexaminingorgansof17-dayfetalmiceforbiologicallyactivemetallothioneinmRNA.Metallothioneinwasidentifiedincell-freetranslationproductsbymigrationinpolyacrylamidegelsanditscharacteristicelutiononSephadexG-50columns.Metallothioneinconstitutes∼7.5%of[35S]cysteineincorporatedintopolypeptidesdirectedbymRNAfromfetalliver,butitisnotdetectableinmRNA-directedproductsoffetalkidney,smallbowel,heart,oradultliver.Consistentwithafetal-specificrole,hepaticmetallothioneinmRNAcontentdecreasesabruptlyinnewbornmice,becomingundetectablewithin12days.
[发布日期] [发布机构]
[效力级别] [学科分类] 生物科学（综合）
[关键词] [时效性]
