Fine structural observations on the origin and associations of primordial germ cells of the mouse☆
[摘要] Thisstudyexplorestheoriginofprimordialgermcells(PGCs)ofthemouseandexaminestheirmorphologyandassociationswithothercellsduringearlydevelopment.PGCshavebeenselectivelystainedbythealkalinephosphatasehistochemicalreactionandviewedbylightandelectronmicroscopyfromthetimetheyarefirstdetectableintheyolksacendodermuntiltheyenterthegonadalridges.ThereareconflictingreportsastowhetherthePGCsoriginatefromendodermalcellsorwhethertheyoriginateelsewhereandsubsequentlyentertheendoderm.TheobservationsinthepresentstudyfavorthepremisethatPGCsofthemousedonotoriginateintheendoderm.Furthermore,itwasobservedthatPGCsundergospecificchangesinmorphologyduringthedevelopmentalperiodstudiedandthiswasinterpretedtomeanthat,althoughPGCsaresetasideearlyindevelopmentasadistinctcellline,theyalsocontinuetobecomemorespecializedwithintime.Thegermcelllineisratherunusualinthatitdoesnotexistasadiscretetissuebut,instead,resideswithinvariousothertissuesduringitslifehistory.Thisapparentdependenceuponsomaticcellsismaintainedeveninadultanimalsandmaybeimportantinservingtomaintainormodifytheenvironmentofthegermcells.
[发布日期] [发布机构]
[效力级别] [学科分类] 生物科学（综合）
[关键词] [时效性]
