Changes in cortisol binding to soluble receptor proteins in rat liver and thymus during development and ageing☆
[摘要] Changesinlabeledcortisolbindingtosolublecytoplasmicproteinsofratliverandthymusduringdevelopmentandageingofanimalshavebeenobserved.Therelationshipofageandcortisolbindingtoafractionofsolubleliverproteinsprecipitatedat50%saturationwithammoniumsulfatedisplayedtwomaxima:Thefirstoneontheseventhdayofpostnatallifeandthesecondoneat2.5monthsofage.Bindingofhormonetomacromoleculesofthesamefractionpreparedfromolderanimalswaslessefficient.Almostthesamepicturehasbeenobtainedwhentotalboundactivitytomacromolecularcytosolfractionwasexpressedpermilligramofdryweightofliver.Bindingoflabeledcortisoltototalcytosolmacromoleculesofliverandthymuswasmostefficientin3-month-oldanimalsanddecreasedafterthat,whichisofinterestinviewoftotallyoppositeeffectsofglucocorticoidsuponvariousbiosyntheticprocessesoftheseorgans.
[发布日期] [发布机构]
[效力级别] [学科分类] 生物科学（综合）
[关键词] [时效性]
