Inter- and intramyotomal gap junctions in the axolotl embryo☆
[摘要] Inearlytailbudembryosoftheaxolotl(Ambystomamexicanum),cellsoftheanteriormyotomesbegintoelongateandalignalongthelongitudinalaxisoftheanimal.Soonthereafter,gapjunctionsappearbetweenthedifferentiatingmyotubes.Thesejunctionsoccurbetweenadjacentcellswithinamyotome(intramyotomal)andbetweenthecellsofadjacentmyotomeswhichareseparatedfromoneanotherbynarrowconnectivetissuesepta(intermyotomal).Thelatterarefoundattheendsoftheelongatingcellswheremuscle-tendoninsertionwilloccurandnerve-musclesynapseswillform.Thegapjunctionsaretransient:Theyappearwiththeonsetofmyofibrillarformationatthetimethatnervefibersentertheintermyotomalsepta.Thejunctionslastuntilthecellshavedifferentiatedintomaturestriatedmusclecellsandneuromuscularsynapsesarefullydeveloped.Thesegapjunctionsmayprovideameansforthedirectintercellularspreadofelectricalexcitationbetweenthedifferentiatingmusclecellsandsoaccountfortheobservedmyogeniccontractionofmyotomes.Wealsosuggestthatthesejunctionsmayformameansforcellularcommunicationandinteractionduringthedevelopmentoftheaxialmusculature.
[发布日期] [发布机构]
[效力级别] [学科分类] 生物科学（综合）
[关键词] [时效性]
