Epithelial-mesenchymal interaction during lung development: The effect of mesenchymal mass
[摘要] Thepurposeofthisstudywastoinvestigatethequantitativeroleofthemesenchymeduringitsinteractionwithepithelium,usingthemouseembryoniclunginorgancultureasamodelsystem.Bymaintainingtheepitheliuminassociationwithdifferentamountsofmesenchymeitwasshown,usinghistologicalandultrastructuralcriteria,thatnotonlyepithelialgrowthandmorphogenesisbutalsotheformofepithelialcytodifferentiationweredependentontheamountofmesenchymepresent.Furthermore,itwasshownthataminimumquantityofmesenchymewasnecessaryforepithelialcellmaintenanceandthatlargerminimumquantitiesofmesenchymewerenecessaryforeachofthethreeaspectsofepithelialdevelopmentstudied:growth,morphogenesis,andcytodifferentiation.
[发布日期] [发布机构]
[效力级别] [学科分类] 生物科学（综合）
[关键词] [时效性]
