Morphogenetic determination of the dermoepidermal interface during tail regeneration in Rana catesbeiana☆
[摘要] Duringregenerationoftheamputatedtadpoletail,reconstructionoftheepithelialbasallaminaandbasementlamellaoccursonlyaftertheothermajormorphogeneticprocessesarewellestablished.At4daysaftertailtransectionofthebullfrogtadpole,electronmicroscopyoftheinternalsurfaceofthebasalcelllayeroftheblastemalepitheliumrevealsittoberelativelyfreeofextracellularmatrix.By11daysabasallaminaofdistinctregularityhasformed,andthefirstrodletsandfiberssignalingthereplacementofthecollagenousbasementlamellaareidentified.At15daysthebasalcellsoftheepitheliumstarttoexhibitspecializationoftheirinternalcellsurfaces:Hemidesmosomesandassociatedtonofilamentsappear,andtheadepidermalglobularlayerisformed.Orthogonalpackingofcollagenpliesbeginsby19daysaftertransection,thenumberoflayersexceeding22inthelatterstagesofregeneration.
[发布日期] [发布机构]
[效力级别] [学科分类] 生物科学（综合）
[关键词] [时效性]
